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Types of Bi-clusters
- Let A = {a1, ..., an} be a set of genes, B = {b1, …, bn} a set of conditions
- A bi-cluster: A submatrix where genes and conditions follow some consistent patterns
- 4 types of bi-clusters (ideal cases)
- Bi-clusters with constant values:
- for any i in I and j in J, eij = c
- Bi-clusters with constant values on rows:
- eij = c + αi
- Also, it can be constant values on columns
- Bi-clusters with coherent values (aka. pattern-based clusters)
- eij = c + αi + βj
- Bi-clusters with coherent evolutions on rows
- (ei1j1− ei1j2)(ei2j1− ei2j2) ≥
- i.e., only interested in the up- or down- regulated changes across genes or conditions without constraining on the exact values
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